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Elevated ROS levels not only damage -cells but also activate stress kinases that interfere with insulin signaling, aggravating insulin resistance

Because Se interferes with S metabolism and can replace S in the S-amino acids which results into the production of the corresponding Se-amino acids (seleno-Cys and selenomethionine), their subsequent incorporation into enzymatic proteins may affect catalytic activity (Ellis and Salt, 2003)

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The cellular availability of Cys and bidirectional flux of cellular thiols across the plasmalemma may influence the interaction of the GST tag